Source data
The register is built directly from
ClinicalTrials.gov v2 API,
the federally-mandated public registry of all U.S. interventional clinical
trials. Branmoor queries for trials in
RECRUITING or ACTIVE_NOT_RECRUITING status with
one or more U.S. site locations, normalizes the site list, and aggregates
site-level metrics across all matching trials.
What v1 reports
Per site (facility × city × state):
- Active trial count — the number of currently-recruiting or active-not-recruiting trials with this site as a study location
- Unique sponsor count — the count of distinct lead sponsors across all active trials at this site
- Top sponsor — the lead sponsor running the most trials at the site (signal of platform relationship vs. one-off engagement)
- Phase distribution — counts of Phase 1, 2, 3, 4, and Early Phase 1 trials at the site (signal of late-stage activity and trial-portfolio risk profile)
What v1 is not
v1 is the activity-volume surface. It is not the risk-score product the full Trial Site Risk Index is designed to deliver. v1 does not include:
- FDA Form 483 / warning letter history — per-PI and per-institution inspection findings. The leading indicator of data-integrity risk at a trial site. PDF extraction is M-effort; planned for the paid layer
- FDA Bioresearch Monitoring (BIMO) inspection results — the trial-specific subset of FDA inspections
- CMS Open Payments — industry payments to physician investigators. Surfaces sponsor-PI financial relationships that may indicate selection bias risk. Clean public CSV; planned
- FDA debarred persons list — PIs barred from clinical research participation. Clean public; planned
- Site-indexed adverse event patterns — FAERS reports matched back to study sites where the events occurred. Imperfect signal; planned
- Composite risk score — weighted combination of the above against historical trial-failure outcomes (FDA refuse-to-file, trial stops, data-integrity-driven enrollment pauses)
The full set is the paid Trial Site Risk Index. See the product page for the paid layer structure and the pharma-sponsor / CRO / plaintiff-firm sales motion.
Update cadence
ClinicalTrials.gov updates trial records continuously as sponsors file protocol amendments, status changes, and enrollment updates. Branmoor re-ingests on each site deploy; the freshness of the register is bounded by sponsor filing cadence (typically daily for active trials).
Limits
Status accuracy on ClinicalTrials.gov is sponsor-self-reported. Some trials remain listed as Recruiting after the sponsor has stopped active enrollment; CMS / FDA can occasionally flag stale records, but the registry generally trusts sponsor filings.
Site facility names are sponsor-reported and not always normalized. “Memorial Sloan Kettering Cancer Center” and “MSKCC” may appear as separate sites for the same institution. The site-aggregation script does case-insensitive exact matching on (facility, city, state); a fuzzy-matching layer is planned to improve cross-system continuity.